Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants.

For example, if one gene is repressed by 1.8-fold, the statistical significance may not be very high, but if all 78 cRPGs are repressed to a similar degree with an average of 1.8-fold, 1.8-fold becomes highly significant (P-value < 0.00001 when compared to background genes).

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