Impact of stringent non-pharmaceutical interventions applied during the second and third COVID-19 epidemic waves in Portugal, 9 November 2020 to 10 February 2021: an ecological study.

Results COVID-19 incidence rate At the onset of the second wave, an increasing trend in COVID-19 incidence was observed in Portugal for the pre-tiered NPIs study period, peaking around tiered NPIs implementation (58.8 daily cases per 100,000 population, on 16 November 2020) ( Figure 1 and Supplementary Figure S1 : COVID-19 incidence and average temperature).

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This methodology analyses the longitudinal effects of an intervention on a given outcome, comparing an expected trend without intervention to the trend found after the intervention [ 9 ].

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