Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila.

Expression of the Drosophila-Inhibitor-of-Apoptosis (DIAP1, UAS-diap ) [ 25 ] or induction of fas2 – cell clones in a heterozygous Df(3L)H99/+ background [ 26 ] produced a barely significant normalization of size in the fas2 – clones, and we did not detect any significant effect at all expressing P35 in the clones ( S1J Fig ).

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Fas2-deficient MARCM clones ( fas2 eB112 , fas2 — ) growing in a Df(3L)H99/+ genetic background displayed a little significant (depending on the statistical test used, t or Mann-Whitney ) normalization of clone size in the adult notum.

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