First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model.

Statistical significance for studies involving two groups were determined by Student’s unpaired t -test whereas statistical significance for studies involving more than two factors were determined by Two-way ANOVA where ns indicated not significant, *indicates p < 0.05 and considered statistically significant, **indicates p < 0.01 and considered very significant, ***indicates p < 0.001 and considered extremely significant and ****indicates p < 0.0001 and considered extremely significant.

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Two-way ANOVA analysis revealed that the differences between body weight and length regardless of gender were highly significant in AAV8-HLP-mGHR treated Laron mice when compared to vector control AAV8-HLP-Luc injected Laron mice.

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