highly significantP <0.00001
Regarding the percent inhibition of paw edema, the main effects of the treatment and time factors were highly significant by the four solutions used ( P <0.00001), and their interaction was also significant ( P =0.006, 0.006, 0.0062, and 0.0058 for Manly’s approach, Edgington’s approach, Still and White’s permutation of residuals and ter Braak’ methods, respectively).