an increasing trendP = 0.069
a decreasing trendP = 0.086
It should be notable that the PRL of the metformin group showed a decreasing trend (from 1737.360 ± 626.918 to 1618.625 ± 640.865, t = 1.759, P = 0.086), while that of the placebo group showed an increasing trend (from 2676.470 ± 1269.234 to 2860.933 ± 1317.376, t = 1.866, P = 0.069).