highly significantP = 1 × 10 −8
A burden test adjusted for sex and the first five principal components for the 15 loci revealed highly significant enrichment in rare homozygous, potential compound heterozygous, or hemizygous variants in patients relative to controls (P = 1 × 10 −8 ; odds ratio = 26.6; 95% confidence interval = 7.3–96.6), with 12 carriers among the patients (10.7%, including four homozygotes, one potential compound heterozygote, and seven hemizygotes) vs. three (0.25%, two homozygotes, one hemizygote) among the controls.