Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy.

Front Pharmacol · 2022 · PMC9207248 · PMID 35734404

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a decreasing trendno p-value reported

As the concentration of IL-1β increased, the expression of SIRT3 showed a decreasing trend ( Figures 2A,B ), a finding that was further validated using RT-qPCR ( Figure 2C ).

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an increasing trendno p-value reported

Overall, SIRT3 expression showed an increasing trend in the presence of higher levels of MA-5 ( Figures 2D,E ), reaching significantly higher levels at 10 μM MA-5.

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