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Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone Versus in Combination with Polynucleotides for the Treatment of Melasma: A Pilot Study.

Dermatol Ther (Heidelb) · 2022 · PMC9209614 · PMID 35538360

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a decreasing trendno p-value reported
Figures 1 , 2 , 3 , and 4 show means with standard deviation of the MI, EI, skin roughness, and mMASI scores for the PN (treatment) and NSS (control) sides from baseline and the five follow-up time points after the final treatment session, showing a decreasing trend.

also in 47,180 other papers

a positive trendno p-value reported
Patients’ self-assessed improvement scores also showed a positive trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.