Point mutations in SARS-CoV-2 variants induce long-range dynamical perturbations in neutralizing antibodies.

So, the N501Y, K417N–E484K–N501Y, and L452R–E484Q mutants show a decreasing trend in the non-equilibrium work required to dissociate the BD23 antibody, and the recovery of the E484 residue in the delta variant regains the binding affinity.

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