Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait association analysis.

3 a); (2) SNPs located at DNase I hypersensitive sites showed highly significant enrichment in several tissues, with colon identified as the most significant enrichment (OR = 5.10, P = 2.74 × 10 −7 ) (Fig. 3 b); (3) SNP enrichment in different chromatin state associated regions revealed that the transcribed regions were significantly enriched in different tissues (embryonic stem cell: OR = 6.18, P = 4.25 × 10 −8 ; liver: OR = 5.55, P = 5.26 × 10 −8 ; blood: OR = 5.13, P = 1.76 × 10 −7 ) (Fig. 3 c).

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