A phylogenetic approach to study the evolution of somatic mutational processes in cancer.

Commun Biol · 2022 · PMC9217972 · PMID 35732905

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a decreasing trendno p-value reported

In lung cancer somatic variation, we detect a decreasing trend of smoking-related mutational processes over time and an increasing influence of APOBEC mutational processes as the tumor evolution progresses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.