Single-cell RNA Sequencing Identified Novel Nr4a1<sup>+</sup> Ear2<sup>+</sup> Anti-Inflammatory Macrophage Phenotype under Myeloid-TLR4 Dependent Regulation in Anti-Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN).

Adv Sci (Weinh) · 2022 · PMC9218767 · PMID 35484716

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highly significantno p-value reported

Thus, the identification of Nr4a1/Ear2‐dependent anti‐inflammatory macrophage population was highly significant both scientifically and clinically since it may imply that the induction of this anti‐inflammatory macrophage population via the Nr4a1/Ear2‐dependent mechanism may represent as a novel immunotherapy for anti‐GBM cGN.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Single-cell RNA Sequencing Identified Novel Nr4a1&lt;sup&gt;+&lt;/sup&gt; Ear2&lt;sup&gt;+&lt;/sup&gt; Anti-Inflammatory Macrophage Phenotype under Myeloid-TLR4 Dependent Regulation in Anti-Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN).

The sentences

Single-cell RNA Sequencing Identified Novel Nr4a1<sup>+</sup> Ear2<sup>+</sup> Anti-Inflammatory Macrophage Phenotype under Myeloid-TLR4 Dependent Regulation in Anti-Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN).