Rivaroxaban and Risk of Venous Thromboembolism in Patients With Symptomatic Peripheral Artery Disease After Lower Extremity Revascularization.

19 , 20 , 21 Statins, which have anti-inflammatory properties, 22 have been associated with 20% to 30% decreased risk of VTE, 23 , 24 , 25 and there was an observed trend for reduction in VTE associated with PCSK9-inhibitor use in acute coronary syndromes, with the risk of VTE related to reduction in the proinflammatory lipoprotein(a), 26 but not low-density lipoprotein cholesterol. 27 Further evidence for shared pathobiology in atherothrombosis and VTE comes from the finding of increased platelet activation in patients with VTE, 28 , 29 suggesting cross-talk between platelet function and coagulation.

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