a nonsignificant trendp = 0.100
Segmented regression analysis results show a significant increase in the consumption of all systemic antibiotics measured in DID in the first wave of the pandemic ( p = 0.015), while a nonsignificant trend of decreased antibiotic consumption was observed in the second wave ( p = 0.100) and the intermediate periods ( p = 0.098) ( Figure 4 A and Table S2 ).