Estrogen Receptor-Regulated Gene Signatures in Invasive Breast Cancer Cells and Aggressive Breast Tumors.

Additionally, numerous genes found in Signature 2 were related to essential biological processes, such as intracellular transport, macromolecular localization, and cell projection organization, although these signatures did not achieve significance ( Figure 3 e).

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We found a highly significant enrichment of both Signatures 1 and 2 in Cluster 4, and a moderate enrichment in Cluster 2 ( Figure 4 b).

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