An independent 40-patient case–control study included in discovery report [ 7 ], confirmed differential expression at 24 weeks of four of the five RNAs for sPTL/PPROM ≤ 32 weeks ( APOA1 approached but did not reach significance).
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Evaluation of a Maternal Plasma RNA Panel Predicting Spontaneous Preterm Birth and Its Expansion to the Prediction of Preeclampsia.
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APOA4 ( p = 0.092), APOA1 ( p = 0.43), and NAMPT ( p = 0.12) did not achieve significance in this cohort.