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The Clinical Relevance of Hypothyroidism in Patients with Solid Non-Thyroid Cancer: A Tantalizing Conundrum.

J Clin Med · 2022 · PMC9224934 · PMID 35743483

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an increasing trendno p-value reported
Generally, during the normal process of aging, normal serum TSH levels show an increasing trend even in the absence of underlying thyroid disease, comorbidities, or the administration of drugs interfering with the thyroid function.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.