TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers.

This ‘exploitation’ of EGR1 function through interaction with TBX2 may be significant in the context of immortalisation, as EGR1 is also known to transcriptionally upregulate p53, p21 WAF1/CIP1 , TGF-β and PTEN; these prominent TSGs are known to perform critical roles in the induction of cellular senescence.

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