Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data.

Molecules · 2022 · PMC9227077 · PMID 35744794

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highly significantno p-value reported

In the case of HSA chromatography, isocratic logk values, measured in the presence of 10% acetonitrile (ACN), were used (logk 10,HSA ), as they showed a highly significant 1:1 correlation with plasma protein binding data in our previous study [ 45 ].

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