Zein-Stabilized Nanospheres as Nanocarriers for Boosting the Aphrodisiac Activity of Icariin: Response Surface Optimization and In Vivo Assessment.

Equation (3), which reveals the coded factor terms of the quadratic model, was generated by the software. (3) Y 3 (entrapment efficiency) = 59.92 + 8.08 X 1 − 5.47 X 2 + 5.01 X 3 − 4.56 X 4 + 2.02 X 1 X 2 − 1.94 X 1 X 3 + 1.66 X 1 X 4 − 0.89 X 2 X 3 − 0.047 X 2 X 4 + 0.34 X 3 X 4 − 1.59 X 1 2 + 1.48 X 2 2 + 1.52 X 3 2 − 1.98 X 4 2 ANOVA results revealed that all the linear terms and the quadratic terms corresponding to the four investigated variables exhibited a markedly significant impact on entrapment efficiency ( p < 0.0001 for all linear terms; p = 0.0192, 0.0160, 0.0314, and 0.0053 for X 1 2 , X 2 2 , X 3 2 , and X 4 2 , respectively).

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