Shotgun Proteomics Revealed Preferential Degradation of Misfolded In Vivo Obligate GroE Substrates by Lon Protease in <i>Escherichia coli</i>.

Of course, since the GroE depletion itself reportedly induces large metabolic changes, including the depletion of several amino acids, S-adenosylmethionine, and NADPH [ 7 ], this phenomenon may be significant only under exceptional metabolic conditions.

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