An interesting trend has been identified using GIBS: an unequal geographical distribution of B Vic and B Yam infections.
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Antibody cross-protection between the two B lineages is assumed to be low [ 4 , 38 ], although some studies suggest cross-reactive serum antibodies may be significant [ 39 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338745/ (accessed on 20 March 2022)—CR16 Under experimental conditions, the B Yam lineage may induce cross-antibody responses to the Victoria lineage, but the opposite is not as efficient [ 40 ].