Pharmacokinetic-Pharmacometabolomic Approach in Early-Phase Clinical Trials: A Way Forward for Targeted Therapy in Type 2 Diabetes.

Pharmaceutics · 2022 · PMC9231303 · PMID 35745841

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an increasing trendno p-value reported

There were 37 metabolites for arginine and proline metabolisms in the KEGG library; the mummichog analysis found an increasing trend in the number of metabolites to hit the pathway from dataset A (24 metabolites) to dataset B (31 metabolites) when the number of subjects increases from 6 subjects to 17 subjects.

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