Mitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: correlations with aging and drug use.

Clin Epigenetics · 2022 · PMC9233363 · PMID 35752846

Europe PMC DOI

hedged sentences

0.0860

closest p · 1.7× alpha

0.0860

boldest claim

The sentences

borderline significantP value = 0.086so close (0.05 < p ≤ 0.1)

When individuals with ATSs and individuals with ketamine in their systems were examined separately, a prominent age acceleration was found among those deceased individuals with the presence of any ketamine ( n = 7) in both the NAcc (an increase of 16.1 years in the median; P value = 0.003) and the PFC (an increase of 13.9 years in the median; P value = 0.006), and a borderline significant age acceleration among those deceased individuals with the presence of any ATS ( n = 9) in both the NAcc ( P value = 0.086) and the PFC ( P value = 0.056).

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borderline significanceno p-value reported

In addition, the variation in age acceleration was wide in ATS users, resulting in the borderline significance of accelerated aging.

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