Identification of a novel splicing mutation and genotype-phenotype correlations in rare PLS3-related childhood-onset osteoporosis.

Orphanet J Rare Dis · 2022 · PMC9233774 · PMID 35752817

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.1800

boldest claim

The sentences

marginally significantp = 0.059so close (0.05 < p ≤ 0.1)

There is a marginally significant negative correlation between age and BMD z-score ( p = 0.059, r = − 0.30).

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failed to reach significancep = 0.18not close (p > 0.1)

Although the correlation between age and efficacy of bisphosphonates therapy failed to reach significance, there is a trend towards less effective in older patients ( p = 0.18, r = 0.34), especially in those aged more than 18 years (Fig. 4 d).

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