Effects of root-end filling materials on vascular endothelial cell proliferation and tube formation.

J Dent Sci · 2022 · PMC9236890 · PMID 35784111

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an increasing trendno p-value reported

20 In the samples soaked for 1 day, MTA showed an increasing trend of VEGFR-1 and VEGFR-2 mRNA expression compared with the control ( Fig. 3 A and B), while the effect of SB was similar to that of the control.

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a decreasing trendno p-value reported

This result is consistent with the report that the cell proliferation of HUVECs peaked on day 4 of culture and showed a decreasing trend on day 7 of culture in the MTA-soaked 1-day sample. 18 MTA has been shown to become highly alkaline at 3 h after kneading. 28 Although there is no report showing a relationship between high alkalinity and suppression of vascular endothelial cell proliferation, it is possible that the high pH value in the early stage of curing may affect proliferation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.