Acute lymphoblastic leukemia displays a distinct highly methylated genome.

Nat Cancer · 2022 · PMC9236905 · PMID 35590059

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a positive trendno p-value reported

Notably, a comparison of global average methylation with average methylation levels of CGIs across patients with ALL revealed a positive trend, especially for the T-ALL samples.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.