Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites.

Nat Commun · 2022 · PMC9237045 · PMID 35760782

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a decreasing trendno p-value reported

L1-ORFeus insertions showed joining to the DSB either direct (no microhomology) or via short microhomologies, mostly 1 bp to 6 bp with a decreasing trend over length (Fig. 2d ), consistent with the microhomologies reported for the 5′-junctions of human L1 insertions that occurred via TPRT 53 .

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