Production of Lentiviral Vectors Using a HEK-293 Producer Cell Line and Advanced Perfusion Processing.

Figure 1D also shows an increasing trend in TVP, where the TVP of the final product of both selected parameter sets (average 3.33 × 10 11 TVP for HCD-C set, average 4.81 × 10 11 TVP for HCD-ME set) are 1 log higher than the baseline parameter set (average 3.89 × 10 10 TVP for LCD set).

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For parameter evaluation in this first set of experiments (shake flasks M1-M6), Figure 1A shows a decreasing trend in both the viable cell density (VCD) and percent cell viability over the time course of LV production, and Figure 1B shows an increase of the TFP and TVP when the strategies of HCD at the TOI, pseudo-perfusion, and feeding are implemented.

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