Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Per-Protocol Analysis of the GLOBAL LEADERS Trial.

15 Yet, the RR estimate of the primary end point showed a nonsignificant trend toward the benefit with the experimental strategy, with the upper boundary of the 95% CI being close to the unit. 15 The intention‐to‐treat principle represents the gold standard for randomized trial analysis to minimize the risk of bias, but it carries some drawbacks. 19 , 20 , 21 First, this analytical approach offers an estimate of the effect of the treatment assignment—and not of the treatment itself.

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