Polyethylene Glycol Loxenatide Injection (GLP-1) Protects Vascular Endothelial Cell Function in Middle-Aged and Elderly Patients With Type 2 Diabetes by Regulating Gut Microbiota.

Front Mol Biosci · 2022 · PMC9240776 · PMID 35782875

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a decreasing trendno p-value reported

an increasing trendno p-value reported

The number of genes showed an increasing trend after W4 of GLP-1 use, but then showed a decreasing trend at W8.

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an overall trendno p-value reported

Changes in gut microbiota at week 0, 4, and 8 after using GLP-1 were not statistically different, but had an overall trend of rising and then falling, and with different bacteria, that were correlated with different clinical indicators.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.