PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.

Mol Ther Nucleic Acids · 2022 · PMC9240963 · PMID 35795486

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a positive trendno p-value reported

Although siRNA constructs containing the smaller 10 kDa PEG moiety showed a positive trend compared with the parent compound, this group only achieved statistically significant improvements in tissue accumulation in the liver and heart ( Figure 2 C).

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