Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration.

Sci Adv · 2022 · PMC9242589 · PMID 35767627

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When the drug concentration was 5 μg ml −1 , the cell viability of CT26 cells in the CP@SiO 2 /Pt@PEG-Glu with NIR laser irradiation (1.5 W cm −2 ) group was only 16.6 ± 0.7%, with highly significant statistical difference compared with the CP, CP@SiO 2 /Pt, and CP@SiO 2 /Pt@PEG-Glu groups (45.5 ± 0.7%, 58.2 ± 0.8%, and 46.3 ± 2.8%, respectively).

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