Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms.

Front Neurosci · 2022 · PMC9243337 · PMID 35784845

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may be significantno p-value reported

Furthermore, alterations in relatively rare cell types such as microglia (~10% of brain cells) may be significant mediators of ND pathogenesis, but are very difficult to detect and distinguish cell-type-specific changes using bulk proteome analysis.

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