Our model is inconsistent with these two studies, as we observed barely significant downregulation of IFN-related gene expression in the CA-treated PIEs vs NT controls upon SADS-CoV infection ( Fig 4E ), suggesting that the innate immune responses in enterocytes might be intrinsically less sensitive to BA exposure.
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Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids.
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