a trend towards significanceP = 0.086
reference score = baseline) yielded a significant treatment difference for dyspnoea (HR 0.71; P = 0.034) and a trend towards significance for chest pain (HR 0.67; P = 0.086); and definition TTD6 (i.e. reference score = best previous) yielded significant differences for cough (HR 0.70; P = 0.009) and dyspnoea (HR 0.71; P = 0.004) and a trend towards significance for chest pain (HR 0.73; P = 0.067).