The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.

Nat Commun · 2022 · PMC9250932 · PMID 35781533

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To confirm this hypothesis, we carried out Gene Set Enrichment Analysis (GSEA) with the LSC gene set that contains upregulated (UP) and downregulated (DN) genes in LSCs 8 , and showed highly significant enrichment of the LSC signature gene set in genes co-regulated with RBM17 in AML patients (Fig. 1i ).

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