Equus roundworms (Parascaris univalens) are undergoing rapid divergence while genes involved in metabolic as well as anthelminic resistance are under positive selection.

Interestingly, the differences in carbohydrate metabolism and lipid metabolism were extremely significant in the two clades (Fig.

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We only considered two types of highly significant factors (metabolism and anthelmintics), and other selection effects still need to be verified in a broader range of P. univalens populations in the future.

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