The Impact of Pharmacogenetics on Pharmacokinetics and Pharmacodynamics in Neonates and Infants: A Systematic Review.

Pharmgenomics Pers Med · 2022 · PMC9252316 · PMID 35795337

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59 Related to ABCC3 polymorphisms (Multidrug Resistance Protein 3), Hahn et al observed a decreasing trend on morphine clearance with MRP3 efflux transporter (rs4793665) genotypes (CC>CT>TT) (morphine clearance, standardized to 70 kg, 31.3, vs 26.39 vs 20.76 L/h, 1.5-fold difference) in a subgroup of OCT1 wild-type cases. 60 Organic Cation Transporters Matic et al reported that the plasma log M/M1 ratio

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