CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue.

Surprisingly, we observed that fasting plasma glucose (mean, 6.38 mmol/L vs 8.6 mmol/L) and HbA1c (mean, 6.39% vs 8.27%) were higher in AA genotype carriers than in GG genotype carriers ( Figure 2 E,F); 2-hour plasma glucose after 75 g oral glucose tolerance test (OGTT) showed an increasing trend in AA genotype group, compared to GG genotype group (mean, 9.14 mmol/L vs 11.97 mmol/L, p = 0.071) ( Table S2 ).

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