Whole lesion histogram analysis of apparent diffusion coefficient predicts therapy response in locally advanced rectal cancer.

Briefly, the Youden index calculation indicated that post-nCRT kurtosis, post-nCRT skewness, and ∆skewness values below 0.78 × 10 -3 mm 2 /s, 1.59 × 10 -3 mm 2 /s, and 0.16, respectively, might be significant indicators of the occurrence of pCR.

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