A highly significant linkage signal (LOD score peak of 72) for ex vivo IL-1β production limited a 4 Mbp interval to chromosome 7.
← all excerpts
<i>Pycard</i> and <i>BC017158</i> Candidate Genes of <i>Irm1</i> Locus Modulate Inflammasome Activation for IL-1β Production.
2
—
—
The sentences
These genes map to the unique and extremely significant Irm1 locus controlling NLRP3 inflammasome activation ( 35 , 36 ).