Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.

6 D); however, there were consistent and highly significant decreases in the M2-like TAMs (Fig. 6 C) that generally paralleled the observed changes in the CD11b+/F4/80+/FRβ TAM population (Fig. 6 B).

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