Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Comparison of TCC levels in App NL−G−F versus WT SN demonstrated a highly significant increase in TCC in APP NL−G−F at 6, 9 and 12 months, more than fourfold greater at 12 months (Fig. 2 c; solid horizontal lines).

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Notably, TCC levels in WT TBH barely changed with age with no significant difference apart from a borderline significant difference between 3 and 12 months; in contrast, TCC levels in App NL−G−F TBH markedly increased with age, more than twofold between 3 and 12 months (Fig. 1 b; dashed horizontal lines.

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