a decreasing trendP = 0.016
An increased trend for tubular damage was noted for waves 1–4 (8.8%, 15.9%, 25.7%, and 29.0%; Z = 16.9, P < 0.001), while glomerular damage showed a decreasing trend (5.6%, 5.5%, 4.4%, and 4.1%; Z = −2.4, P = 0.016; Table 1 ).