Impact of Previous Local Treatment for Brain Metastases on Response to Molecular Targeted Therapy in BRAF-Mutant Melanoma Brain Metastasis: A Systematic Review and Meta-Analysis.

Front Oncol · 2022 · PMC9263360 · PMID 35814449

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a slight trendp = 0.08so close (0.05 < p ≤ 0.1)

Consequently, a slight trend towards better PFS ( p = 0.08) was observed with no significant improvement in OS.

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almost significantp = 0.08so close (0.05 < p ≤ 0.1)

Subgroup analysis revealed that a significant improvement in PFS ( p = 0.03) and an almost significant OS ( p = 0.08) could be achieved in previously treated BMs when analysis was restricted to patients receiving a combination of dabrafenib and trametinib and patients with BRAFV600K (Val600Lys) mutation.

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