The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8⁺ T lymphocyte-mediated neurotoxicity.

However, perioperative stroke mice presented with only an increasing trend with respect to spatial learning impairment without statistical significance as compared with stroke-only mice ( P = 0.8251, Fig. 2 E).

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