Healthcare Burden of Rare Diseases: A Population-Based Study in Tuscany (Italy).

Concerning the average LOS, a decreasing trend was observed up to 2014 (7.8 days), followed by an increase up to a quite steady trend in the last years (8.3 days in 2018) ( Figure 4 ).

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In particular, the main discharge diagnoses due to endocrine, nutritional and metabolic diseases, and immunity disorders showed an increasing trend from 2009 (7.2%) to 2013 (11.7%), followed by a steady trend until 2016 and a decrease until the end of the study period, with percentages ranging between 11.3% and 13.8% ( Figure 5 a).

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