MGMT and Whole-Genome DNA Methylation Impacts on Diagnosis, Prognosis and Therapy of Glioblastoma Multiforme.

By contrast, among patients whose tumors were not MGMT methylated, the addition of temozolomide to radiotherapy had only a marginally significant impact on survival; this trial finally established MGMT gene methylation status as a biomarker for predicting response to temozolomide and, in turn, a powerful prognostic factor [ 15 ].

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